Route 66 Barstow California: Museums, Historic Hotels & Highlights

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Barstow, California – Route 66 Town Profile

Crossroads of Opportunity

Barstow is the “Crossroads of Opportunity,” where Route 66, I‑15, and I‑40 meet. Its Main Street carries the Mother Road’s spirit, offering travelers historic landmarks, neon motels, and desert adventures at the heart of California’s Route 66.

Route 66 Highlights

Route 66 Mother Road Museum

📍 681 N 1st Ave
Located inside the historic Harvey House. It functions as Barstow’s de facto Route 66 visitor center.

Casa del Desierto Harvey House

📍 685 North 1st Avenue
Houses the Route 66 Mother Road Museum, the Western America Railroad Museum, and still functions as an Amtrak station.

Skyline Drive-In Theatre

📍 31175 Old Highway 58
A retro two-screen drive-in movie spot that accommodates about 600 cars.

Mojave River Valley Museum

📍 270 E. Virginia Way
Features over 4,000 square feet of exhibits, a gift shop, and archives dating back to 1911, with admission always free.

Calico Ghost Town

📍 36600 Ghost Town Road, Yermo Restored silver mining town near Barstow, California, founded in 1881 and now preserved as a San Bernardino County Regional Park.